Supporting research in Virtual Physiological Human modelling
VPH Modelling Support Service is a suite of simulation-based software services aimed at supporting researchers defining new Virtual Physiological Human models.
VPH-MSS enables researchers in VPH modelling to simulate their models with or without drug administrations.
VPH models typically contain several parameters. Different values to these parameters yield different model behaviours and capture the physiological differences among different patients.
VPH-MSS enables researchers to compute populations of virtual patients by intelligently searching for parameter values entailing model behaviours satisfying given biological properties (for example, characterising one or more classes of real patients).
Populations of virtual patients are the starting point to enable in silico clinical trials.
VPH-MSS enables researchers to validate their candidate VPH models against large amounts of retrospective clinical data, showing to which extent evolutions of the VPH model can match available patient observations.
Like all software services developed within Paeon, VPH-MSS is not restricted to reproductive endocrinology VPH models, as it is ready to be used with other Virtual Physiological Human Models and other drugs.
VPH Model Simulator is a tool within the VPH-MSS suite which allows Researchers in VPH Modelling to interactively run their VPH models with and without drug administrations. The VPH Model Simulation console provides the user with the time evolution of the model variables (for example, biological species), in order to support test and tuning of the input VPH model.
VPH Virtual Patient Population Builder is a tool within the VPH-MSS suite which allows Researchers in VPH Modelling to build populations of virtual patients for their VPH models. The tool intelligently explores the space of values for the VPH model parameters for assignments which yield model evolutions satisfying the given (biological) criteria. Each such assignment to model parameters is a Virtual Patient.
Complete (with respect to VPH model evolutions) populations of virtual patients are the starting point to validate the input VPH model against clinical data and to enable in silico clinical trials by exploiting the other Paeon software services.
VPH Model Validator is a tool within the VPH-MSS suite which allows Researchers in VPH Modelling to validate their VPH models against clinical data, computing to what extent their VPH model can reproduce the measurements available in the input dataset.