The PAEON project developed a suite of methods and software tools to support development of improved personalised Assisted Reproduction Techniques (ART).
PAEON benefits are delivered to clinicians, researchers, hospitals and educational institutions through the cloud based PAEON Platform offering a suite of software services intended to support:
1. Physicians, thanks to software tools that help in the analysis of clinical situations and in taking decisions during treatments.
2. Medical researchers and treatment designers, thanks to software services enabling in-silico (i.e., through simulation) evaluation of effectiveness of treatment protocols.
3. Students and medical interns, thanks to software tools that helps learning about human physiology and about treatment protocols.
PAEON software services are based on mathematical models of the human menstrual cycle (virtual patients), under normal as well as pathological conditions, of treatment protocols (virtual doctor): models enable quantitative predictions about time-dependent hormone concentrations and follicle dynamics under normal conditions as well as during treatments. This vision is summarized in the following figure.
Moreover, during the project lifetime we collected prospective clinical data (both on untreated and treated patients) as a result of PAEON activities by partner hospitals (University Hospital Zurich and Hannover Medical School). We also collected a substantial amount of retrospective clinical data from project partner University Hospital Zurich as well as a result of networking activity with University Hospital of Lausanne and University Hospital of Basel.